As of the census of 2000, there were 1,432 people, 583 households, and 303 families residing in the CDP. The population density was 439.9 people per square mile (169.6/km²). There were 616 housing units at an average density of 189.2/sq mi (73.0/km²). The racial makeup of the CDP was 62.22% White, 33.80% African American, 0.07% Native American, 2.51% Asian, 0.56% from other races, and 0.84% from two or more races. Hispanic or Latino of any race were 1.82% of the population.
There were 583 households out of which 25.9% had children under the age of 18 living with them, 29.2% were married couples living together, 17.3% had a female householder with no husband present, and 48.0% were non-families. 43.6% of all households were made up of individuals and 24.7% had someone living alone who was 65 years of age or older. The average household size was 2.14 and the average family size was 2.96.
In the CDP the population was spread out with 21.9% under the age of 18, 9.8% from 18 to 24, 25.4% from 25 to 44, 16.8% from 45 to 64, and 26.0% who were 65 years of age or older. The median age was 40 years. For every 100 females there were 72.5 males. For every 100 females age 18 and over, there were 64.4 males.
The median income for a household in the CDP was $22,321, and the median income for a family was $44,625. Males had a median income of $38,393 versus $19,700 for females. The per capita income for the CDP was $21,868. About 14.0% of families and 19.5% of the population were below the poverty line, including 25.7% of those under age 18 and 21.5% of those age 65 or over.
Prince Frederick has served as the county seat of Calvert County since 1722, when officials chose a plot of land known as "Williams' Old Field" as the spot for the new county courthouse. (Contemporary references to the piece of land include an upscale dining restaurant named Old Field Inn, and a street in Prince Frederick is named "Old Field Lane.") The original courthouse was finally completed in 1732. The town was most likely named for Frederick, Prince of Wales, who reigned during the time of the town's original conception.
In the War of 1812, Commodore Joshua Barney's Chesapeake Bay Flotilla found refuge from the advancing British in St. Leonard's Creek in June 1814. While laying siege to Barney's force, the British under the command of Admiral Sir Alexander Cochrane plundered and destroyed the area nearby, including burning the town of Prince Frederick..
Solomons Island Road is the major north-south artery through Prince Frederick and carries two Maryland Route designations: Maryland Route 2 which runs from Baltimore to Solomons and Maryland Route 4, an extension of Pennsylvania Avenue from Washington, D.C., which continues past Solomons over the Governor Thomas Johnson Bridge across the Patuxent River to St. Mary's County. Route 4 was dualized in the mid-1970s and commuter buses run on it to Washington, D.C. Routes 2 and 4 join north of Prince Frederick near Sunderland. Route 2 from there north is only a two-lane road to Annapolis.
Maryland Route 231 intersects Solomons Island Road and runs west, ultimately crossing the Patuxent River and continuing into Charles County. Maryland Route 765 serves as Prince Frederick's Main Street and provides access to the courthouse and government center.
In the mid 1990s, a series of new loop roads and side streets were approved in Prince Frederick in order to divert local traffic off of Route 2-4 and alleivate thru-traffic congestion. The first of these roads, Prince Frederick Boulevard, has already been completed between Maryland Route 231 and Stoakley Road. Additional roads are planned around the eastern and southern portions of town..
Institutions and organizations
Louis L. Goldstein, Maryland Comptroller of the Treasury 1959-1998; born in Prince Frederick, MD, in 1913. Known for his phrase "God Bless Y'all Real Good".
Roger Brooke Taney, the Chief Justice of the U.S. Supreme Court in the Dred Scott decision was born and raised on a farm near Prince Frederick.
Best-selling author Tom Clancy operated an insurance business in Prince Frederick prior to his bookwriting career and was an active parishioner of St. John Vianney Catholic Church, and still owns a home near Prince Frederick on the Chesapeake Bay.
Noted theoretical ecologist Dr. Robert Ulanowicz currently resides in Prince Frederick and teaches at the nearby Chesapeake Biological Laboratory.
Former U.S. House of Representatives member Augustus Rhodes Sollers lived and practiced law in Prince Frederick.